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Methane metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
methanol + coenzyme_M <=> methyl-CoM + H2O 2.1.1.246 [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.90 methanol---corrinoid protein Co-methyltransferase
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(2S)-lactyl-2-diphospho-5''-guanosine + coenzyme_F0 <=> GMP + coenzyme_F420-0 2.7.8.28 2-phospho-L-lactate transferase
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7-Oxoheptanoic_acid <=> 7-Mercaptoheptanoic_acid not assigned
 –
Dimethylamine + coenzyme_M <=> methyl-CoM + methylamine 2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.249 dimethylamine---corrinoid protein Co-methyltransferase
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5,6,7,8-tetrahydromethanopterin + formylmethanofuran + H+ <=> 5-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran 2.3.1.101 formylmethanofuran---tetrahydromethanopterin N-formyltransferase
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H+ + Trimethylamine_N-oxide <=> Dimethylamine + formaldehyde 4.1.2.32 trimethylamine-oxide aldolase
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coenzyme_B + coenzyme_M + coenzyme_F420 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> CoM-S-S-CoB + reduced_coenzyme_F420 + oxidized_ferredoxin 1.8.98.4 coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
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methane + hydroquinone + O2 <=> methanol + 1,4-benzoquinone + H2O 1.14.18.3 methane monooxygenase (particulate)
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5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine 2.1.2
2.1.2.1 glycine hydroxymethyltransferase
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CO + H2O + oxidized_ferredoxin <=> CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.4 anaerobic carbon monoxide dehydrogenase
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(2S)-2-phospholactate + GTP + H+ <=> L-lactyl-2-diphospho-5''-guanosine + diphosphate 2.7.7.68 2-phospho-L-lactate guanylyltransferase
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formate + coenzyme_F420 + H+ <=> CO2 + reduced_coenzyme_F420 1.17.1.9 formate dehydrogenase
1.17.98.3 formate dehydrogenase (coenzyme F420)
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oxidized_ferredoxin + formylmethanofuran + H2O <=> reduced_ferredoxin_[iron-sulfur]_cluster + methanofuran + CO2 + H+ 1.2.7.12 formylmethanofuran dehydrogenase
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2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
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(-)-threo-iso(homo)2citrate + NAD+ <=> 2-oxopimelic_acid + CO2 + NADH 1.1.1
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formate + NAD+ <=> CO2 + NADH 1.17.1.10 formate dehydrogenase (NADP+)
1.17.1.9 formate dehydrogenase
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(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate 3.1.3.71 2-phosphosulfolactate phosphatase
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pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.1 pyruvate synthase
1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
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4-(hydroxymethyl)-2-furancarboxaldehyde_phosphate + L-alanine <=> 5-(aminomethyl)-3-furanmethanol_phosphate + pyruvate 2.6.1.108 (5-formylfuran-3-yl)methyl phosphate transaminase
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(3S)-3-carboxy-3-hydroxypropanoyl-CoA <=> glyoxylate + acetyl-CoA 4.1.3.24 malyl-CoA lyase
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formaldehyde + NAD+ + H2O <=> formate + NADH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.22 lactaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.32 aminomuconate-semialdehyde dehydrogenase
1.2.1.46 formaldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
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acetyl-CoA + tetrahydrosarcinapterin <=> CoA + 5-methyltetrahydrosarcinapterin + CO not assigned
 –
(Z)-hex-1-ene-1,2,6-tricarboxylate + H2O <=> (-)-threo-iso(homo)3citrate 4.2.1.114 methanogen homoaconitase
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5,10-methylenetetrahydromethanopterin + coenzyme_F420 + H+ <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced_coenzyme_F420 1.5.98.1 methylenetetrahydromethanopterin dehydrogenase
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O2 + methanol <=> H2O2 + formaldehyde 1.1.3.13 alcohol oxidase
1.1.3.6 cholesterol oxidase
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dihomocitrate + CoA + H+ <=> 2-oxoadipate + acetyl-CoA + H2O 2.3.3
4.1.3
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S-hydroxymethylglutathione + NAD+ <=> S-formylglutathione + NADH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
1.2.1.46 formaldehyde dehydrogenase
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phosphate + acetyl-CoA <=> acetyl_phosphate + CoA 2.3.1.19 phosphate butyryltransferase
2.3.1.222 phosphate propanoyltransferase
2.3.1.8 phosphate acetyltransferase
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ATP + beta-D-fructose_6-phosphate <=> H+ + ADP + D-fructose_1,6-bisphosphate 2.7.1.105 6-phosphofructo-2-kinase
2.7.1.11 6-phosphofructokinase
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beta-D-fructose_6-phosphate + ADP <=> H+ + D-fructose_1,6-bisphosphate + AMP 2.7.1.146 ADP-specific phosphofructokinase
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5,10-methylenetetrahydromethanopterin + NADP+ <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH 1.5.1
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H+ + 2-Oxosuberate <=> pimelic_semialdehyde + CO2 not assigned
 –
S-adenosyl-L-methionine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil <=> coenzyme_F0 + 5''-deoxyadenosine + L-methionine + NH3 + H+ 4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
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coenzyme_B + coenzyme_M + methanophenazine <=> CoM-S-S-CoB + dihydromethanophenazine 1.8.98.1 dihydromethanophenazine:CoB-CoM heterodisulfide reductase
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trimethylamine + H2O + flavin <=> Dimethylamine + formaldehyde + reduced_flavodoxin 1.5.8.2 trimethylamine dehydrogenase
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methylamine + coenzyme_M <=> NH3 + methyl-CoM 2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.248 methylamine---corrinoid protein Co-methyltransferase
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D-glycerate + ATP <=> H+ + 2-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase
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trihomocitrate <=> (Z)-hex-1-ene-1,2,6-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
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methanol + NAD+ <=> H+ + formaldehyde + NADH 1.1.1.1 alcohol dehydrogenase
1.1.1.202 1,3-propanediol dehydrogenase
1.1.1.244 methanol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.B4
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acetyl-CoA + 5,6,7,8-tetrahydromethanopterin <=> CoA + 5-Methyl-5,6,7,8-tetrahydromethanopterin + CO not assigned
 –
GTP + coenzyme_F420-1 + L-glutamate <=> GDP + phosphate + coenzyme_gamma-F420-2 6.3.2.34 coenzyme F420-1:gamma-L-glutamate ligase
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D-arabino-hex-3-ulose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.27 6-phospho-3-hexuloisomerase
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H+ + 3-sulfopyruvate <=> 2-sulfoacetaldehyde + CO2 4.1.1.79 sulfopyruvate decarboxylase
4.1.1.82 phosphonopyruvate decarboxylase
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S-formylglutathione + H2O <=> H+ + formate + glutathione 3.1.1.56 methylumbelliferyl-acetate deacetylase
3.1.2.12 S-formylglutathione hydrolase
3.1.2.6 hydroxyacylglutathione hydrolase
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CoA + acetate + ATP <=> acetyl-CoA + diphosphate + AMP 6.2.1.1 acetate---CoA ligase
6.2.1.17 propionate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
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glyoxylate + L-serine <=> Hydroxypyruvate + glycine 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.35 glycine---oxaloacetate transaminase
2.6.1.4 glycine transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
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(Z)-pent-1-ene-1,2,5-tricarboxylate + H2O <=> (-)-threo-iso(homo)2citrate 4.2.1.114 methanogen homoaconitase
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trimethylamine + coenzyme_M <=> methyl-CoM + Dimethylamine 2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.250 trimethylamine---corrinoid protein Co-methyltransferase
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2-sulfoacetaldehyde <=> coenzyme_M not assigned
 –
phosphoenolpyruvate + CO2 <=> phosphate + oxaloacetate 4.1.1.31 phosphoenolpyruvate carboxylase
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dihydroxyacetone + ATP <=> H+ + dihydroxyacetone_phosphate + ADP 2.7.1.28 triokinase
2.7.1.29 glycerone kinase
2.7.1.30 glycerol kinase
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5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 <=> 5,10-methylenetetrahydromethanopterin + H+ 1.12.98.2 5,10-methenyltetrahydromethanopterin hydrogenase
1.12.99.6 hydrogenase (acceptor)
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coenzyme_F420 + H2 <=> reduced_coenzyme_F420 1.12.98.1 coenzyme F420 hydrogenase
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H+ + trihomocitrate + CoA <=> 2-oxopimelic_acid + acetyl-CoA + H2O 2.3.3
4.1.3
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coenzyme_B + coenzyme_M + oxidized_ferredoxin <=> CoM-S-S-CoB + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.8.7.3 ferredoxin:CoB-CoM heterodisulfide reductase
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5-Methyl-5,6,7,8-tetrahydromethanopterin + coenzyme_F420 <=> 5,10-methylenetetrahydromethanopterin + reduced_coenzyme_F420 1.5.98.2 5,10-methylenetetrahydromethanopterin reductase
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gamma-glutamyltyramine + [5-(aminomethyl)furan-3-yl]methyl_diphosphate <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate 2.5.1.131 (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
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methylamine + H2O + amicyanin <=> formaldehyde + NH3 + reduced_amicyanin + H+ 1.4.9.1 methylamine dehydrogenase (amicyanin)
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dihomocitrate <=> (Z)-pent-1-ene-1,2,5-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
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H2O + acceptor + N-Methyl-L-glutamate <=> L-glutamate + reduced_acceptor + formaldehyde 1.5.99.5 methylglutamate dehydrogenase
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7-Mercaptoheptanoylthreonine + ATP <=> H+ + coenzyme_B + ADP 2.7.1
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2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 4.2.1.11 phosphopyruvate hydratase
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L-glutamate + tyramine + ATP <=> gamma-glutamyltyramine + ADP + phosphate + H+ 6.3.4.24 tyramine---L-glutamate ligase
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H+ + L-tyrosine <=> CO2 + tyramine 4.1.1.25 tyrosine decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
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ATP + coenzyme_gamma-F420-2 + L-glutamate <=> ADP + phosphate + coenzyme_alpha-F420-3 6.3.2.32 coenzyme gamma-F420-2:alpha-L-glutamate ligase
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L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase
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D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase
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trimethylamine + O2 + NADPH <=> Trimethylamine_N-oxide + H2O + NADP+ 1.14.13.148 trimethylamine monooxygenase
1.14.13.8 flavin-containing monooxygenase
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5,10-methylenetetrahydromethanopterin + H2O <=> formaldehyde + 5,6,7,8-tetrahydromethanopterin 4.2.1.147 5,6,7,8-tetrahydromethanopterin hydro-lyase
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S-adenosyl-L-methionine + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-tyrosine <=> 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + 5''-deoxyadenosine + L-methionine + H+ 2.5.1.147 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
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D-arabino-hex-3-ulose_6-phosphate <=> D-ribulose_5-phosphate + formaldehyde 4.1.2.43 3-hexulose-6-phosphate synthase
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formylmethanofuran + H2O <=> methanofuran + formate 1.2.7.12 formylmethanofuran dehydrogenase
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methane + NADH + O2 + H+ <=> methanol + NAD+ + H2O 1.14.13.230 butane monooxygenase (soluble)
1.14.13.25 methane monooxygenase (soluble)
1.14.18.3 methane monooxygenase (particulate)
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coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> CoM-S-S-CoB + H2 + oxidized_ferredoxin 1.8.98.5 H2:CoB-CoM heterodisulfide,ferredoxin reductase
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5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H+ + 5-formyl-5,6,7,8-tetrahydromethanopterin 3.5.4.27 methenyltetrahydromethanopterin cyclohydrolase
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methyl-CoM + coenzyme_B <=> CoM-S-S-CoB + methane 2.8.4.1 coenzyme-B sulfoethylthiotransferase
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formate + NADP+ <=> CO2 + NADPH 1.17.1.10 formate dehydrogenase (NADP+)
1.17.1.9 formate dehydrogenase
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(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase
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trimethylamine + 2 ferricytochrome_c + H2O <=> Trimethylamine_N-oxide + 2 ferricytochrome_c + 2 H+ 1.7.2.3 trimethylamine-N-oxide reductase
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(2R)-O-phospho-3-sulfolactate <=> phosphoenolpyruvate + sulfite + H+ 4.4.1.19 phosphosulfolactate synthase
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7-Mercaptoheptanoate + L-threonine + ATP <=> H+ + 7-Mercaptoheptanoylthreonine + ADP + phosphate not assigned
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methylamine + L-glutamate <=> N-Methyl-L-glutamate + NH3 2.1.1.21 methylamine---glutamate N-methyltransferase
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D-glyceraldehyde_3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde_phosphate + H2O + phosphate 4.2.3.153 (5-formylfuran-3-yl)methyl phosphate synthase
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D-glycerate + NAD+ <=> H+ + Hydroxypyruvate + NADH 1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.26 glyoxylate reductase
1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.29 glycerate dehydrogenase
1.1.1.60 2-hydroxy-3-oxopropionate reductase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.92 oxaloglycolate reductase (decarboxylating)
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5-(aminomethyl)-3-furanmethanol_phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl_diphosphate + ADP 2.7.4.31 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase
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H2O + pyruvate + ATP <=> H+ + phosphate + phosphoenolpyruvate + AMP 2.7.1.40 pyruvate kinase
2.7.9.2 pyruvate, water dikinase
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O-phospho-L-serine + H2O <=> L-serine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.15 histidinol-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.8 3-phytase
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3-phospho-D-glycerate + NAD+ <=> H+ + 3-phosphohydroxypyruvate + NADH 1.1.1.95 phosphoglycerate dehydrogenase
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D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
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(-)-threo-iso(homo)3citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH 1.1.1
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methanol + ferricytochrome_b5 <=> formaldehyde + ferricytochrome_b5 + H+ 1.1.2.10 lanthanide-dependent methanol dehydrogenase
1.1.2.7 methanol dehydrogenase (cytochrome c)
1.1.2.e
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GTP + coenzyme_F420-0 + L-glutamate <=> GDP + phosphate + coenzyme_F420-1 6.3.2.31 coenzyme F420-0:L-glutamate ligase
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Dimethylamine + H2O + flavin <=> methylamine + formaldehyde + reduced_flavodoxin 1.5.8.1 dimethylamine dehydrogenase
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(2R)-3-sulfolactate + NAD+ <=> H+ + 3-sulfopyruvate + NADH 1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
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coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + CO2 <=> CoM-S-S-CoB + formate + oxidized_ferredoxin 1.8.98.6 formate:CoB-CoM heterodisulfide,ferredoxin reductase
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S-hydroxymethylglutathione <=> formaldehyde + glutathione 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
4.4.1.22 S-(hydroxymethyl)glutathione synthase
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formaldehyde + D-xylulose_5-phosphate <=> dihydroxyacetone + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
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(S)-malate + CoA + ATP <=> phosphate + (3S)-3-carboxy-3-hydroxypropanoyl-CoA + ADP 6.2.1.5 succinate---CoA ligase (ADP-forming)
6.2.1.9 malate---CoA ligase
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O-phospho-L-serine + 2-oxoglutarate <=> L-glutamate + 3-phosphohydroxypyruvate 2.6.1.52 phosphoserine transaminase
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ATP + acetate <=> ADP + acetyl_phosphate 2.1.2.2 phosphoribosylglycinamide formyltransferase
2.7.2.1 acetate kinase
2.7.2.15 propionate kinase
2.7.2.2 carbamate kinase
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formaldehyde + H2O <=> methanol + formate + H+ 1.2.98.1 formaldehyde dismutase
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Visualization of the pathway